Cryptococcus neoformans-derived microvesicles enhance the pathogenesis of fungal brain infection.
Pocket Knife Cryptococcal meningoencephalitis is the most common fungal disease in the central nervous system.The mechanisms by which Cryptococcus neoformans invades the brain are largely unknown.In this study, we found that C.neoformans-derived microvesicles (CnMVs) can enhance the traversal of the blood-brain barrier (BBB) by C.neoformans invitro